Monday, March 31, 2008

Evidence for Safety & Efficacy of Mesotherapy

Mesotherapy is performed by thousands of doctors worldwide for fat destruction. The safety & efficacy of this procedure is often questioned by medical professionals not familiar with it.

These are just a few papers published in reputable medical journals that look at what happens to the fat after treatment, whether it works and whether it is safe. There is none so blind as those who won't see. Mesotherapy may be slow, but there is good evidence that it is effective and safe.

[1]
Dermatol Surg. 2008 Jan;34(1):60-6; discussion 66.

Phosphatidylcholine and sodium deoxycholate in the treatment of localized fat: a double-blind, randomized study.

Salti G, Ghersetich I, Tantussi F, Bovani B, Lotti T.
Centro Chirurgico Florence, Florence, Italy. giosal@fol.it

Each patient received injections of a phosphatidylcholine/sodium deoxycholate preparation on one side and sodium deoxycholate on the contralateral side, each single patient being herself the control. Four treatments were carried out every 8 weeks in a double-blind, randomized fashion.

Both treatments have shown moderate and equivalent efficacy in treating localized fat, with sodium deoxycholate having a slower postoperative resolution, suggesting that sodium deoxycholate could be sufficient by itself to determine fat cell destruction and that phosphatidylcholine could be useful for obtaining a later emulsification of the fat.

[2] Dermatol Surg. 2004 Jul;30(7):1001-8.

Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution.

Rotunda AM, Suzuki H, Moy RL, Kolodney MS.
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.

Cell viability and cell membrane lysis assays were performed on cell cultures and porcine skin after treatment with the phosphatidylcholine formula, isolated sodium deoxycholate, or common laboratory detergents Triton-X 100 and Empigen BB.

A significant and comparable loss of cell viability, cell membrane lysis, and disruption of fat and muscle architecture was seen in cell cultures and tissue specimens treated with the phosphatidylcholine formula and isolated sodium deoxycholate.

[3] Dermatol Surg. 2007 Feb;33(2):178-88; discussion 188-9.

Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects.

Yagima Odo ME, Cucé LC, Odo LM, Natrielli A.
Department of Dermatology, School of Medicine, University of Santo Amaro, São Paulo, Brazil. marina.odo@uol.com.br

Sodium deoxycholate (SD) induces an inflammatory reaction in subcutaneous human fat and dose-dependent adipocyte lysis with acute pain and fibrosis. No systemic effects were detected.

[4] Dermatol Surg. 2006 Apr;32(4):465-80

Mesotherapy and phosphatidylcholine injections: historical clarification and review.

Rotunda AM, Kolodney MS.

Department of Dermatology, University of Southern California School of Medicine, Los Angeles, California, USA. arotunda@hotmail.com

All the published studies evaluating the clinical efficacy of traditional mesotherapy currently originate from Europe. These reports focus primarily on musculoskeletal pain and vascular disease, rather than cosmetic applications. Although experimental data suggest that a number of traditional mesotherapy ingredients may theoretically reduce fat, these effects have not been supported in peer-reviewed studies. An increasing number of reports demonstrate that subcutaneous injections of a formula containing phosphatidylcholine combined with its emulsifier, deoxycholate, are effective in removing small collections of adipose tissue. Cell lysis, resulting from the detergent action of deoxycholate, may account for this clinical effect.

Mesotherapy is distinct from a method of treating adipose tissue with subcutaneous injections of deoxycholate alone or in combination with phosphatidylcholine.

[5] J Cosmet Dermatol. 2007 Dec;6(4):250-7.

Submental fat reduction by mesotherapy using phosphatidylcholine alone vs. phosphatidylcholine and organic silicium: a pilot study.

Co AC, Abad-Casintahan MF, Espinoza-Thaebtharm A.
Jose R. Reyes Memorial Medical Center, Rizal Avenue, Sta. Cruz, Manila, Philippines. genjoabby@hotmail.com

Mesotherapy using phosphatidylcholine vs. phosphatidylcholine plus organic silicium was similarly effective in reducing submental fat. There was no significant difference between them in terms of rate and degree of reduction. Optimal reduction of submental fat was achieved after three treatment sessions. Adverse reactions were few, mild, and transitory. Therefore, both regimens are safe, efficacious, cost-effective, and can be used as alternatives to invasive surgical procedures.

[6] J Drugs Dermatol. 2003 Oct;2(5):511-8

Phosphatidylcholine in the treatment of localized fat.

Hexsel D, Serra M, Mazzuco R, Dal'Forno T, Zechmeister D.
Doris Hexsel Dermatologic Clinic, Porto Alegre, Brazil. dohexsel@zaz.com.br

Clinical results reflect that phosphatidylcholine was efficacious in reducing the fatty pads in the treated areas, with few side effects. From the authors' point of view, the off-label use of phosphatidylcholine in the treatment of fatty pads and small areas of localized fat is safe, low cost, and effective.

[7] J Cosmet Laser Ther. 2005 Mar;7(1):17-9.

Histological changes associated with mesotherapy for fat dissolution.

Rose PT, Morgan M.

Punch biopsies were taken at one and two weeks after mesotherapy with PC and DC. Each of the biopsies taken at one and two weeks after treatment with PC and DC showed a normal epithelium and dermis, with a mixed septal and lobular panniculitis. The fat lobules were infiltrated by increased numbers of lymphocytes and, in particular, macrophages. The macrophages consisted of conventional forms, foam cells, and multinucleated fat-containing giant cells. The inflammation was associated with serous atrophy and microcyst formation.

[8] Aesthetic Plast Surg. 2006 Jul-Aug;30(4):474-8.

Injection of phosphatidylcholine in fat tissue: experimental study of local action in rabbits.

Rittes PG, Rittes JC, Carriel Amary MF.
Santa Casa School of Medicine, Rua Afonso Braz, 864, cj. 72, Vila Nova Conceição, São Paulo, SP, Brazil. prittes@terra.com.br

Using a randomized, blind approach, 10 rabbits were injected with an experimental assay of phosphatidylcholine (the biologic model), and another 10 rabbits were injected with physiologic saline. A histologic study was conducted, and the Mann-Whitney test was applied.

A marked difference was observed between the two groups with respect to necrosis, inflammatory exudation, and fibrosis.

[9] Aesthetic Plast Surg. 2003 Jul-Aug;27(4):315-8.

The use of phosphatidylcholine for correction of localized fat deposits.

Rittes PG.

Subjects with localized fat deposits commonly receive suction lipectomy as a cosmetic procedure. A new office procedure for correction of those superficial fat deposits was applied in 50 patients by injection of phosphatidylcholine. The method itself consists of using a 3OG1/2 insulin needle to inject about 5 ml (250 mg/5 ml) of phosphatidylcholine into the fat, distributing it evenly in an 80 cm2 area. Pre- and posttreatment photographs were taken for technical planning and analysis of the results over the long term.

A clear improvement occurred in all, with a marked reduction of the fat deposits without recurrence over a 2-year follow-up period and no weight gain. The injection of phosphatidylcholine into the fat deposits is a simple office procedure that can sometimes postpone or even replace surgery and liposuction.

[10] Dermatol Surg. 2001 Apr;27(4):391-2.

The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads.

Rittes PG.
Clínica Patrícia Rittes, Sao Paulo, Brazil. prittes@ruralsp.com.br

Thirty patients were treated for prominent lower eyelid fat pads with phosphatidylcholine injection. Pre- and posttreatment photographs were taken for long-term analysis. A marked reduction of the lower eyelid fat pads was noted over the 2-year follow-up period. There were no recurrences.

The injection of phosphatidylcholine (250 mg/5 ml) into the fat pads is a simple office procedure that may postpone or even substitute for lower eyelid blepharoplasty.

[11] J Cosmet Dermatol. 2006 Sep;5(3):218-26.

Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: a multicentre, retrospective UK study.

Palmer M, Curran J, Bowler P.
British Association of Cosmetic Doctors, 30b Wimpole St, London, UK. mark.palmer@mail.com

Thirty-nine UK doctors specifically trained and experienced in this treatment completed questionnaires, focusing on outcome and adverse effects experienced by patients. Ten thousand five hundred and eighty-one treatments had been administered over a mean duration of 13.1 months. Localized adverse effects (swelling, erythema, burning/stinging, pain, tenderness and bruising) were described by most patients as "very mild' (18.4%) or "mild" (39.2%). The total incidence of systemic side-effects was 3%: diarrhoea, nausea, dizziness/light-headedness and intermenstrual bleeding were described by most patients as "very mild" (36%) or "mild" (55%). Only 15 (0.14%) "unexpected, unusually severe or prolonged" adverse reactions (commonly pain and/or swelling) were reported. These were all self-limiting and none were judged as serious. 73.8% of patients were either "very satisfied" or "satisfied" with treatment.

This treatment appears to be associated with minimal risks when used by specifically trained and experienced doctors. The possible risks associated with this treatment should be balanced against the risks of other treatment options.

[12] J Am Acad Dermatol. 2005 Dec;53(6):973-8.

Lipomas treated with subcutaneous deoxycholate injections.

Rotunda AM, Ablon G, Kolodney MS.
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA. arotunda@hotmail.com

All lipomas decreased in size (mean area reduction, 75%; range, 37%-100%) as determined by clinical measurement (with ultrasound confirmation in one lipoma) after an average of 2.2 treatments. Several lipomas fragmented or became softer in addition to decreasing in volume. Adverse effects, including transient burning, erythema, and local swelling, were associated with higher deoxycholate concentrations but resolved without intervention. There was no clear association between deoxycholate concentration and efficacy. Low concentration deoxycholate may be a relatively safe and effective treatment for small collections of fat.


Friday, March 28, 2008

Lipo Laser Enhances Liposuction Recovery



Our unit arrives next week. WAL is already reputed for quick recovery. This addition will cut down discomfort, bruising and swelling even more!

Sunday, March 23, 2008

MOH to let professionals regulate aesthetic treatments

Source: Channel News Asia
By Hoe Yeen Ni, Channel NewsAsia | Posted: 23 March 2008 2134 hrs

SINGAPORE: The Health Ministry appears to have changed its stand on aesthetic treatments and what procedures can be performed.

It now says it will leave the regulation of the industry to professional bodies, while it turns its attention to the safety of patients instead.

Health Minister Khaw Boon Wan said there is a lot of "grey area" in the industry and it is "not possible" for the Ministry to stop doctors from performing aesthetic treatments if there is a demand.

Mr Khaw clarified the MOH's position following media reports surrounding last week's crackdown on doctors who perform unproven procedures.

The MOH said that regulating the beauty industry is especially challenging as in many cases, scientific evidence is missing or inconclusive.

Furthermore, it added, taking a hard, regulatory approach will mean the prohibition of many procedures. This is not practical and it is not what MOH is advocating, stressed Mr Khaw.

The MOH's remarks came just a few days after it issued what amounted to a ban on certain procedures, such as fat-zapping mesotherapy, application of stem cells to revive the skin or the use of anti-ageing hormone and skin-whitening shots.

It said these have no scientific evidence and should not be practised at all, whether or not the operator has had training.

The MOH had also issued a stern warning that any doctor found doing these "unsubstantiated" procedures will be referred to the Singapore Medical Council for disciplinary review.

But now, that stand seems to have been changed.

"Because I'm not familiar with mesotherapy, I don't even know what it is. So let's leave it to the professions to sort it out," said Mr Khaw.

"The human urge to do this kind of things are plentiful. So who are we to say, stop it? We can't do that," he added.

But what the MOH will do is that it will regulate on high-risk, highly-invasive procedures.

Mr Khaw said his Ministry is working out guidelines which will stipulate who can perform what treatments.

He declined to indicate when the guidelines will be published.

The Academy of Medicine and the College of Family Physicians are also formulating principles to govern the ethical practice of all procedures.

But the question remains -- can doctors carry on in the meantime?

"Doctors are supposed to do what they think appropriate, taking into account possible benefits, and then possible risks. So that's a decision which doctors have to make all the time. Because if they fail to do that, they could be subject to investigation," said Mr Khaw.

Mr Khaw also said that consumers should know what they are getting into before taking the beauty plunge. - CNA/ir

Thursday, March 20, 2008

Quoted When No Comments Were Made!

From Straits Times front page on 20th March 2008:

The ministry began cracking down on such practices from September last year, telling about 20 of the bigger operators to stop.

Prominent plastic surgeon Woffles Wu and anaesthetist Christine Cheng were among those targeted. They complied immediately.

Dr Cheng was unhappy to have been singled out, and asked why the ministry did not inform all doctors.

The ministry explained that it did not realise earlier how widespread aesthetic medicine had become.

*****************************************************************

I have been receiving phone calls non-stop since 2 am London time. Amazing how I ended up in the newspaper when I did not make those comments!

The e-mail interviews follow. I made no comments on the situation at all, given that I was out of town with no access to the newspapers!


*****************************************************************
Dear Dr Cheng,
The MOH has expressed concern over doctors providing what it calls "unsubstantiated practices" including mesotherapy which I believe your clinic offers.
Its concern is not that such treatments are given, but that it fears patients may think they are proper medical treatments as they are done by doctors.
Could I have your comments on this please?
Do you, perhaps, tell your patients that these are not scientifically proven methods?
Or do you disagree with the MOH's stand that there is no backing for these treatments?
Yours Sincerely,
Salma Khalik
Health Correspondent
The Straits Times
Tel: 6319 5349

*****************************************************************
Hi Salma

We no longer offer mesotherapy after the MoH ban.

Cheers!

Dr Christine Cheng
Simply Aesthetic
Tel: 6732 5527
Fax: 6732 5517
www.simply-aesthetic.com

*****************************************************************

Hi Dr Cheng,
Thanks for reply.
Several doctors I spoke to yesterday have received that letter, but others have not - am querying MOH on that.
Does the ban involve only mesotherapy or the other 10 listed in the Straits Times today too?
Has stopping mesotherapy affected your business much - are patients unhappy? If so, any patients I could talk to?
More importantly, do you agree with the ban, since it can still be offered by beauty saloons?
Cheers,
Salma Khalik

*****************************************************************

Hi Salma

We have been advising our patients to undergo liposuction for the last few months, so the ban on mesotherapy has little impact on our business. I am in London at the moment, so do not know which treatments are no longer permissible in clinics. I have yet to speak to my patients regarding their feelings regarding this ban.

I do not know what goes on in beauty salons.

Cheers!

Dr Christine Cheng

*****************************************************************

Hi Christine,
sorry to get back to you again, with you in London.
But have just found out that MOH only sent letters to 20 doctors asking them to stop treatments like mesotherapy and carboxytherapy. Many others offering these services have not been told to stop.
Do you think this is fair?
Or is there some reason why these 20 doctors, including you, have been asked to stop?
Cheers,
Salma Khalik

*****************************************************************

Hi Salma

I have no idea why our Ministry works in this way. With the Hong Kong Medical Council, all registered doctors were notified regarding stopping the use of Phosphatidylcholine via e-mail. So it was fair to all. They did not ban the entire spectrum of mesotherapy, just the main drug used for fat melting. For your information, the injection of steroids into inflamed tendons is considered mesotherapy too. As is the injection of steroids to reduce the thickness of keloid scars.

Filipino doctor presents sheep placenta to fight aging skin

By Cheche Moral
Philippine Daily Inquirer
First Posted 20:15:00 03/13/2008

MANILA, Philippines—If someone had told you the elusive elixir of youth can be found in the sheep’s placenta, you probably wouldn’t have believed it.

But a pioneering cosmetic procedure that uses exactly that—ovine placenta—to delay facial skin aging had its global launch this week in Makati City.

Dr. Florencio Q. Lucero, a cosmetic surgeon who broke ground in stem-cell therapy in the country, introduced the sheep placenta-derived ActiStem Dermal, a liquid solution that aims to stimulate the body’s inactivate stem cells to regenerate skin.

Stem cells are the building blocks of human life. They make up the tissues of the body, and their ability to renew and replicate is responsible for, say, the healing of wounds.

As one ages, however, the body’s capacity to regenerate slows down. But Lucero said reactivating dormant cells via this sheep-derived protein complex can again increase the body’s collagen and elastin production.

Collagen is the component that gives skin its plumpness, elastin its elasticity.

In 2006, Lucero introduced in the country the adipose- or fat-derived stem-cell transplant, aimed at patients with degenerative diseases like Parkinson’s. It was developed with Dr. Bill Paspaliaris of StemTech Ltd. Hong Kong, who provided him with the stem cell technology.

“You activate the cell from the inside to better regenerate. So why not apply it on the skin? It’s the same principle,” Lucero said. He also partnered with Paspaliaris’ firm to develop ActiStem Dermal.

“It’s the first of its kind in the world, and we’re the first to use it,” Lucero said, adding, “Well, they have a similar one in Korea, but how they make it is different.” ActiStem Dermal is awaiting approval in Singapore.

Not stem cell

As with the adipose-derived stem cell therapy, which uses cells from fat suctioned from the patient’s own body and not from human embryos, Lucero said he foresees no moral or ethical issues arising from the use of ActiStem Dermal.

In some countries like Russia, the use of stem cell from human embryos in beauty procedures has raised moral and religious questions.

“You have to understand that [ActiStem Dermal] is not stem cell,” he stressed. “It’s a protein extract from the sheep’s placenta... Sheep [is used because it] is closer to the immunological profile of humans compared to cows, which are used in other so-called stem cell therapy products.” The use of ovine (sheep) placenta was developed in Australia.

According to Dr. Francisca Roa, the dermatologist who conducted the clinical tests for the product, there was “slight to moderate improvement” in the skin’s fine lines, firmness and radiance in the test subjects six weeks after the procedure.

A biopsy of the subjects’ skin samples revealed that 80 percent showed increased collagen production, and 40 percent increased their elastin. Elastin has lesser regenerating qualities compared to collagen, Roa explained. Collagen production decreases by 1 percent each year after the age of 40, she added.

The launch at Ascott Makati was attended by former beauty queens, now in their 40s and 50s, including two Miss Universes. Peachy Veneracion, 48, a former Mutya ng Pilipinas, is the face of ActiStem Dermal.

Non-invasive

A session of ActiStem Dermal costs P25,000, with results lasting up to six months.

It may be administered in three different ways: with a mesogun, the same gadget used in mesotherapy, which mimics the motion of a sewing machine to deliver the drug onto the skin; with a dermal roller, a paint roller-like device with micro needles that creates minute channels on the skin for better drug absorption; or via microinjections, which uses tiny needles.

The procedure is non-invasive, meaning no surgery is involved. It can take from 15-60 minutes to perform. As no downtime is required, a patient can resume with her/his normal activities immediately after a session.

According to Dr. Roa, the test subjects reported minimal itchiness and irritation immediately after the procedure, but these disappeared within minutes. Patients with high sensitivity and low-pain threshold may require some topical anesthesia, particularly with microinjection.

An increase in uric acid, the liver enzyme SGPT and muscle enzyme SGOT were observed in some of the 30 test subjects—28 women and two men, aged 40-65. But they were “within comfortable levels,” making the drug safe for use for patients without pre-existing conditions like diabetes, liver disease, allergies or infections.

As if to make a point, Tinette Lucero, the doctor’s wife, said she has undergone the same procedure. “Whatever my husband uses on me, I assure you it must be safe.”

Wednesday, March 19, 2008

In Pursuit of Youth

Source: Manila Standard Today


By Dinna Chan Vasquez

The beauty business is a multi-billion-dollar industry worldwide because nearly every woman is in search of the magic potion that would stop aging. Sadly, aging is an inevitable reality.

Once a woman is in her middle 20s, collagen production slows and the dermal elastin becomes less elastic. Collagen gives skin its plumpness while elastic provides elasticity.

Bad habits like unprotected sun exposure, repetitive facial expressions, smoking, late nights and many others can result in skin going from balat sibuyas to balat kalabaw.

The sad results of skin aging are fine wrinkling, thin and uneven skin tone, loss of underlying fat leading to hollowed cheeks and eye sockets and loss of firmness on the hands and neck.

Fernando Lucero, one of the country’s most renowned plastic surgeons, says there is no way anyone can prevent aging, pointing to the picture of a wrinkled and stooped old woman.

“We will all end up like that, if we live long enough,” he says.

Lucero, who broke ground in stem cell therapy in the country, is an advocate of ActiStem dermal, a solution derived from sheep placenta that was created to stimulate the body’s stem cells.

Stem cells serve as a sort of repair system for the body. They can theoretically divide without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

Lucero explains that ActiStem dermal is a natural ingredient that, when administered to the skin’s dermal layer, activates stem cells to regenerate faster and more efficiently. The result, he adds, is a marked increase in the production of collagen and elastic and an improvement in the skin’s overall youthfulness. What ActiStem contains are a variety of peptide growth factors such as EGF, FGF, HGF, PDGF among others. Once administered into the dermis, there will be a significant increase in the skin’s collagen and elastin content.

ActiStem dermal promises to deliver in terms of lifting and tightening of the skin, delivering improved radiance or glow and a marked reduction in fine wrinkles.

Clinical tests conducted on 30 patients have confirmed ActiStem dermal’s efficacy as a minimally invasive way to increase collagen and elastin.

Each patient in the trial received one vial of ActiStem dermal administered via mesotherapy. After six weeks, all patients reported moderate or marked improvement of fine lines, with 20 percent giving an excellent rating and 80 percent a moderate rating. For radiance and glow, 16.67 percent gave a marked improvement rating and 83.33 percent gave a moderate improvement rating.

Francesca Roa, the dermatologist who conducted the clinical tests for the product, says there was “slight to moderate improvement” in the skin’s fine lines, firmness and radiance in the test subjects.

Based on a biopsy of the subjects’ skin, 80 percent showed increased collagen production and 40 percent increased their elastin.

Roa says the subjects reported minimal itchiness and irritation immediately after the procedure but these disappeared after a few minutes.

Former beauty queen Peachy Veneracion tried ActiStem and says she started to notice a change in her face after only one week.

“My face became more radiant. After two weeks, my skin became less haggard. I also noticed that since I had the treatment, I have not had a single pimple on my face and my pores have become smaller,” says the Mutya ng Pilipinas 1977 titlist.

Lucero says what makes ActiStem dermal more ground-breaking, aside from the fact that it is minimally invasive, is that the procedure requires 20 minutes of the person’s time and produces no swelling or irritation.

With no recovery time necessary, patients can go back to their normal activities immediately after the treatment,” he adds.

Lucero’s wife Tinette also used ActiStem dermal and she says her skin is more supple, healthy-looking and youthful as a result.

“I have tried many anti-aging creams and even some rejuvenation machines. But with ActiStem, my skin got a little lift and my skin looked tighter. My fine lines and age spots lessened and my skin became smoother since the pores became smaller. My skin has that youthful glow,” she adds.

Sunday, March 9, 2008

Acne Scar Reduction: Moving Beyond Dermaroller Therapy

We have treated dozens of people with acne scars of varying types and depths over the last year. The results have been gratifying, as we inevitably see improvement over the course of the treatment. The majority of our patients call it a day after completing their package of 3 sessions. A few have agreed to continuing treatment and adding other modes of therapy to enhance the results.

Over the last few months, we have added a variety of treatments to speed up and enhance the results. Peeling was our first adjunct and the results have been dramatic. We now have two other adjuncts which have a part to play in acne scar therapy.

A few weeks ago, we happened to come across a forum discussing autologous collagen to fill up rolling acne scars. We had a volunteer willing to try this treatment. We harvested the collagen from his love handles and injected the substance into the deeper scars. He came back for review today, and was extremely pleased with the outcome. Many deep scars had filled up. Even the scars in his temple area were more shallow.

The next stage of his treatment will involve our latest treatment. We are now able to stimulate collagen production more precisely within each scar, and ablate the sharp edges. Some downtime is associated with this, but it doesn't last long.

There is no single perfect treatment for acne scars. However, each treatment in our range of options has a part to play for optimal results.

Saturday, March 1, 2008

Face Slimming Gel


We have been using the eCO2 Gel mask after Dermaroller treatments as this mask has potent skin soothing properties.

I have just found out from Dr Claudine Roura that this mask can be used for facial slimming too!

This is a brief description of the product's properties:

Face Slimming, Deep Moisturization, Antiaging Care : eCO2GEL If you have ever tried our eCO2GEL packing agent, you must have been amazed by its skin texture refining, whitening, brightening, and lift-up effects. Our newest technology aims to strengthen the superior performance of eCO2GEL with deep moisturization and face slimming effects Deep Moisturization As it is well known, a typical skin care regimen includes the basic step of supplying water and retaining moisture in the skin. Supplying moisture to skin is absolutely essential. In addition, retaining the moisture in the stratum corneum is indispensable, especially in dry seasons like autumn and winter in Japan or for people who tend to have dry skin conditions. Our eCO2GEL.EX incorporates oil, which plays the function of retaining the excellent skin moisture and oil balance after CO2 packing. Furthermore, when skin is dry or skin metabolism is slowed, aging signs such as wrinkles, rough skin etc. appear. On top of our eCO2GEL technology, eCO2GEL.EX technology delivers and supplies essential oil to skin effectively, and helps retain the healthy conditions of skin after CO2 packing. Therefore, it prevents aging sign formation. Face Slimming Effect One of the main components of skin is phospholipid, which forms bi-layers. When skin is treated with eCO2GEL.EX, polyalcohols in the gel base is expected to enter the phospholipid bi-layer by CO2 DDS, and the bi-layer structure may become more organized and compacted. Therefore a face slimming effect can be observed. In the case of eCO2GEL.EX, both polyalcohols and oils in the gel base is expected to enter the phospholipid bi-layer, an even more organized and compacted structure is formed. Therefore, a stronger face slimming effect is expected. This is a true and fast slimming method without going through the painful process of weight loss.

How interesting! I must find out more about this, particularly the protocol. Watch this space!